Ser124

Site Information
GDEEEPDsAPEKGRS SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 28030293

In vivo Characterization
Methods used to characterize site in vivo:	[32P] ATP in vitro ( 1 ) , mass spectrometry ( 2 , 3 ) , mass spectrometry (in vitro) ( 1 ) , mutation of modification site ( 1 )
Disease tissue studied:	prostate cancer ( 1 )
Relevant cell line - cell type - tissue:	COS (fibroblast) ( 1 ) , IEC-6 (epithelial) ( 2 ) , liver ( 3 ) , PC3 (prostate cell) ( 1 )

Downstream Regulation
Effects of modification on biological processes:	apoptosis, inhibited ( 1 ) , transcription, induced ( 1 )

References
1	de Thonel A, et al. (2014) Regulation of the proapoptotic functions of prostate apoptosis response-4 (Par-4) by casein kinase 2 in prostate cancer cells. Cell Death Dis 5, e1016 24457960 Curated Info
2	Courcelles M, et al. (2013) Phosphoproteome dynamics reveal novel ERK1/2 MAP kinase substrates with broad spectrum of functions. Mol Syst Biol 9, 669 23712012 Curated Info
3	Lundby A, et al. (2012) Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. Nat Commun 3, 876 22673903 Curated Info