Ser556
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Home > Phosphorylation Site Page: > Ser556  -  FAF1 (human)

Site Information
EREAIRLsLEQALPP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 27996217

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 1 ) , immunoprecipitation ( 1 ) , mass spectrometry ( 1 , 2 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Disease tissue studied:
lung cancer ( 1 ) , non-small cell lung cancer ( 1 ) , non-small cell lung adenocarcinoma ( 1 )
Relevant cell line - cell type - tissue:
A549 (pulmonary) ( 1 ) , E.coli (bacterial) ( 1 ) , HEK293T (epithelial) ( 1 ) , HeLa (cervical) ( 2 )

Upstream Regulation
Regulatory protein:
TBK1 (human) ( 1 )
Putative in vivo kinases:
IKKE (human) ( 1 )
Kinases, in vitro:
IKKE (human) ( 1 )
Treatments:
chloroquine ( 1 ) , virus infection ( 1 )

Downstream Regulation
Effects of modification on FAF1:
acetylation ( 1 ) , intracellular localization ( 1 ) , molecular association, regulation ( 1 ) , phosphorylation ( 1 ) , protein degradation ( 1 ) , ubiquitination ( 1 )
Effects of modification on biological processes:
signaling pathway regulation ( 1 ) , transcription, induced ( 1 )
Induce interaction with:
GCN5 (human) ( 1 )

References 

1

Dai T, et al. (2018) FAF1 Regulates Antiviral Immunity by Inhibiting MAVS but Is Antagonized by Phosphorylation upon Viral Infection. Cell Host Microbe 24, 776-790.e5
30472208   Curated Info

2

Sharma K, et al. (2014) Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling. Cell Rep 8, 1583-94
25159151   Curated Info