Lys530
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Home > Acetylation Site Page: > Lys530  -  RIPK1 (human)

Site Information
PPTDESIkyTIyNST   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 27992509

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry (in vitro) ( 1 ) , modification-specific antibody ( 1 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Disease tissue studied:
fibrosarcoma of soft tissue ( 1 )
Relevant cell line - cell type - tissue:
heart ( 1 ) , L929 (fibroblast) ( 1 ) , MEF (fibroblast) ( 1 )

Upstream Regulation
Regulatory protein:
RIPK3 (human) ( 1 )
Treatments:
AGK2 ( 1 ) , ischemia/reperfusion ( 1 ) , Necrostatin-1 ( 1 ) , siRNA ( 1 ) , TNF ( 1 ) , tubacin ( 1 ) , Z-VAD-FMK ( 1 )

Downstream Regulation
Effects of modification on RIPK1:
molecular association, regulation ( 1 )
Inhibit interaction with:
RIPK3 (human) ( 1 )

References 

1

Narayan N, et al. (2012) The NAD-dependent deacetylase SIRT2 is required for programmed necrosis. Nature 492, 199-204
23201684   Curated Info

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