Lys67
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Home > Sumoylation Site Page: > Lys67  -  CLOCK (human)

Site Information
MLPGNARkMDKSTVL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 27992507

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , modification-specific antibody ( 1 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Disease tissue studied:
breast cancer ( 1 )
Relevant cell line - cell type - tissue:
COS7 (fibroblast) ( 1 ) , MCF-7 (breast cell) ( 1 ) , T47D (breast cell) ( 1 )

Upstream Regulation
Regulatory protein:
SENP2 (human) ( 1 ) , SENP3 (human) ( 1 )
Treatments:
17-beta-estradiol ( 1 )

Downstream Regulation
Effects of modification on CLOCK:
molecular association, regulation ( 1 )
Effects of modification on biological processes:
cell cycle regulation ( 1 ) , cell growth, induced ( 1 ) , signaling pathway regulation ( 1 ) , transcription, induced ( 1 )
Induce interaction with:
ER-alpha (human) ( 1 )

References 

1

Li S, et al. (2013) CLOCK is a substrate of SUMO and sumoylation of CLOCK upregulates the transcriptional activity of estrogen receptor-α. Oncogene 32, 4883-91
23160374   Curated Info

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