Thr372
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Home > Phosphorylation Site Page: > Thr372  -  MOR-1 (human)

Site Information
sTRIRQNtRDHPstA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447785

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 , 2 ) , mass spectrometry ( 1 ) , mutation of modification site ( 2 , 3 ) , phospho-antibody ( 2 , 3 ) , western blotting ( 2 , 3 )
Disease tissue studied:
breast cancer ( 3 ) , neuroblastoma ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Treatments:
1DMe ( 1 ) , DAMGO ( 1 , 2 ) , EGF ( 3 ) , etorphine ( 2 ) , fentanyl ( 2 ) , morphine ( 2 )

Downstream Regulation
Effects of modification on MOR-1:
receptor internalization, altered ( 3 )

References 

1

Moul├ędous L, et al. (2012) GRK2 protein-mediated transphosphorylation contributes to loss of function of ╬╝-opioid receptors induced by neuropeptide FF (NPFF2) receptors. J Biol Chem 287, 12736-49
22375000   Curated Info

2

Zheng H, et al. (2011) Modulating {micro}-Opioid Receptor Phosphorylation Switches Agonist-dependent Signaling as Reflected in PKC{epsilon} Activation and Dendritic Spine Stability. J Biol Chem 286, 12724-33
21292762   Curated Info

3

Chen Y, et al. (2008) EGF Transregulates Opioid Receptors through EGFR-mediated GRK2 Phosphorylation and Activation. Mol Biol Cell 19, 2973-83
18463167   Curated Info