Thr372
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Home > Phosphorylation Site Page: > Thr372  -  MOR-1 (human)

Site Information
sTRIRQNtRDHPstA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447785

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 , 3 ) , mass spectrometry ( 2 ) , mutation of modification site ( 3 , 4 ) , phospho-antibody ( 1 , 3 , 4 ) , western blotting ( 1 , 3 , 4 )
Disease tissue studied:
breast cancer ( 4 ) , neuroblastoma ( 2 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 1 , 3 , 4 ) , MEF (fibroblast) ( 3 ) , SH-SY5Y (neural crest) ( 2 ) , SKBr3 (breast cell) ( 4 )

Upstream Regulation
Treatments:
1DMe ( 2 ) , AT-034 ( 1 ) , AT-121 ( 1 ) , AT-201 ( 1 ) , AT-324 ( 1 ) , cebranopadol ( 1 ) , DAMGO ( 2 , 3 ) , EGF ( 4 ) , etorphine ( 3 ) , fentanyl ( 3 ) , morphine ( 3 )

Downstream Regulation
Effects of modification on MOR-1:
receptor internalization, altered ( 4 )

References 

1

Dasgupta P, et al. (2022) Attenuated G protein signaling and minimal receptor phosphorylation as a biochemical signature of low side-effect opioid analgesics. Sci Rep 12, 7154
35504962   Curated Info

2

Moulédous L, et al. (2012) GRK2 protein-mediated transphosphorylation contributes to loss of function of μ-opioid receptors induced by neuropeptide FF (NPFF2) receptors. J Biol Chem 287, 12736-49
22375000   Curated Info

3

Zheng H, et al. (2011) Modulating {micro}-Opioid Receptor Phosphorylation Switches Agonist-dependent Signaling as Reflected in PKC{epsilon} Activation and Dendritic Spine Stability. J Biol Chem 286, 12724-33
21292762   Curated Info

4

Chen Y, et al. (2008) EGF Transregulates Opioid Receptors through EGFR-mediated GRK2 Phosphorylation and Activation. Mol Biol Cell 19, 2973-83
18463167   Curated Info

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