Lys554
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Home > Sumoylation Site Page: > Lys554  -  TIF1B (human)

Site Information
LAGMAIVkEEETEAA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 2798310

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 ) , mutation of modification site ( 4 )
Disease tissue studied:
breast cancer ( 4 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 4 ) , 293NS3 (epithelial) ( 1 ) , MCF-7 (breast cell) ( 4 ) , T47D (breast cell) ( 4 )

Downstream Regulation
Effects of modification on TIF1B:
acetylation ( 4 ) , methylation ( 4 )
Effects of modification on biological processes:
cell growth, induced ( 4 ) , transcription, inhibited ( 4 )

References 

1

Tammsalu T, et al. (2014) Proteome-wide identification of SUMO2 modification sites. Sci Signal 7, rs2
24782567   Curated Info

2

Goodarzi AA, Kurka T, Jeggo PA (2011) KAP-1 phosphorylation regulates CHD3 nucleosome remodeling during the DNA double-strand break response. Nat Struct Mol Biol 18, 831-9
21642969   Curated Info

3

Li X, et al. (2007) Role for KAP1 serine 824 phosphorylation and sumoylation/desumoylation switch in regulating KAP1-mediated transcriptional repression. J Biol Chem 282, 36177-89
17942393   Curated Info

4

Lee YK, Thomas SN, Yang AJ, Ann DK (2007) Doxorubicin down-regulates Kruppel-associated box domain-associated protein 1 sumoylation that relieves its transcription repression on p21WAF1/CIP1 in breast cancer MCF-7 cells. J Biol Chem 282, 1595-606
17079232   Curated Info