Lys779
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Home > Sumoylation Site Page: > Lys779  -  TIF1B (human)

Site Information
FNkLTEDkADVQsII   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 2798309

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 , 3 , 5 , 7 , 8 ) , mutation of modification site ( 10 ) , western blotting ( 8 )
Disease tissue studied:
breast cancer ( 10 )
Relevant cell line - cell type - tissue:

Downstream Regulation
Effects of modification on TIF1B:
acetylation ( 10 ) , methylation ( 10 )
Effects of modification on biological processes:
cell growth, induced ( 10 ) , transcription, inhibited ( 10 )

References 

1

Hendriks IA, et al. (2014) Uncovering global SUMOylation signaling networks in a site-specific manner. Nat Struct Mol Biol 21, 927-36
25218447   Curated Info

2

Impens F, Radoshevich L, Cossart P, Ribet D (2014) Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli. Proc Natl Acad Sci U S A 111, 12432-7
25114211   Curated Info

3

Tammsalu T, et al. (2014) Proteome-wide identification of SUMO2 modification sites. Sci Signal 7, rs2
24782567   Curated Info

4

Lamoliatte F, et al. (2013) Targeted identification of SUMOylation sites in human proteins using affinity enrichment and paralog-specific reporter ions. Mol Cell Proteomics 12, 2536-50
23750026   Curated Info

5

Galisson F, et al. (2011) A novel proteomics approach to identify SUMOylated proteins and their modification sites in human cells. Mol Cell Proteomics 10, M110.004796
21098080   Curated Info

6

Goodarzi AA, Kurka T, Jeggo PA (2011) KAP-1 phosphorylation regulates CHD3 nucleosome remodeling during the DNA double-strand break response. Nat Struct Mol Biol 18, 831-9
21642969   Curated Info

7

Matic I, et al. (2010) Site-specific identification of SUMO-2 targets in cells reveals an inverted SUMOylation motif and a hydrophobic cluster SUMOylation motif. Mol Cell 39, 641-52
20797634   Curated Info

8

Blomster HA, et al. (2010) In vivo identification of sumoylation sites by a signature tag and cysteine-targeted affinity purification. J Biol Chem 285, 19324-9
20388717   Curated Info

9

Li X, et al. (2007) Role for KAP1 serine 824 phosphorylation and sumoylation/desumoylation switch in regulating KAP1-mediated transcriptional repression. J Biol Chem 282, 36177-89
17942393   Curated Info

10

Lee YK, Thomas SN, Yang AJ, Ann DK (2007) Doxorubicin down-regulates Kruppel-associated box domain-associated protein 1 sumoylation that relieves its transcription repression on p21WAF1/CIP1 in breast cancer MCF-7 cells. J Biol Chem 282, 1595-606
17079232   Curated Info