Lys356

Site Information
ySSSTKVkDEYMVAE SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 2798307

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 1 ) , mutation of modification site ( 3 )
Disease tissue studied:	gastric cancer ( 3 ) , gastric carcinoma ( 3 )
Relevant cell line - cell type - tissue:	AGS (gastric) ( 3 ) , HEK293T (epithelial) ( 3 ) , HeLa (cervical) [SUMO2 (human), transfection, SUMO2 K0 Q87R (lysine-deficient SUMO2, with Q87R to create convenient Trypsin cleavage site)] ( 1 )

Downstream Regulation
Effects of modification on biological processes:	transcription, inhibited ( 3 )

References
1	Hendriks IA, et al. (2014) Uncovering global SUMOylation signaling networks in a site-specific manner. Nat Struct Mol Biol 21, 927-36 25218447 Curated Info
2	Impens F, Radoshevich L, Cossart P, Ribet D (2014) Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli. Proc Natl Acad Sci U S A 111, 12432-7 25114211 Curated Info
3	Chupreta S, et al. (2007) Sumoylation-dependent control of homotypic and heterotypic synergy by the Kruppel-type zinc finger protein ZBP-89. J Biol Chem 282, 36155-66 17940278 Curated Info