Lys56
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Home > Sumoylation Site Page: > Lys56  -  KLF1 (mouse)

Site Information
PsLHVSLkSEDPSGE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 2798306

In vivo Characterization
Methods used to characterize site in vivo:
electrophoretic mobility shift ( 1 , 3 ) , immunoassay ( 2 ) , immunoprecipitation ( 3 ) , modification-specific antibody ( 3 ) , mutation of modification site ( 1 , 2 , 3 ) , western blotting ( 1 , 2 , 3 )
Disease tissue studied:
leukemia ( 3 ) , chronic myelogenous leukemia ( 3 )
Relevant cell line - cell type - tissue:
bone marrow ( 3 ) , HEK293T (epithelial) ( 3 ) , K562 (erythroid) ( 3 ) , MEL (erythroid) ( 2 , 3 )

Upstream Regulation
Regulatory protein:
PIAS3 (human) ( 3 ) , PIAS4 (human) ( 3 ) , PKCT (mouse) ( 2 )

Downstream Regulation
Effects of modification on KLF1:
intracellular localization ( 2 ) , molecular association, regulation ( 2 , 3 ) , sumoylation ( 2 )
Effects of modification on biological processes:
carcinogenesis, inhibited ( 1 ) , cell differentiation, inhibited ( 3 ) , transcription, inhibited ( 3 )
Induce interaction with:
CHD-4 (human) ( 3 ) , KPNB1 (human) ( 2 )

References 

1

Shyu YC, et al. (2022) Genetic Disruption of KLF1 K74 SUMOylation in Hematopoietic System Promotes Healthy Longevity in Mice. Adv Sci (Weinh) 9, e2201409
35822667   Curated Info

2

Shyu YC, et al. (2014) Tight regulation of a timed nuclear import wave of EKLF by PKCθ and FOE during Pro-E to Baso-E transition. Dev Cell 28, 409-22
24576425   Curated Info

3

Siatecka M, Xue L, Bieker JJ (2007) Sumoylation of EKLF promotes transcriptional repression and is involved in inhibition of megakaryopoiesis. Mol Cell Biol 27, 8547-60
17938210   Curated Info

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