Ser116

Site Information
QEGNRRHssLIDIDS SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 468584

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 1 ) , mutation of modification site ( 3 ) , phospho-antibody ( 3 ) , western blotting ( 3 )
Disease tissue studied:	HER2 positive breast cancer ( 1 ) , luminal A breast cancer ( 1 ) , luminal B breast cancer ( 1 ) , breast cancer, triple negative ( 1 )
Relevant cell line - cell type - tissue:	293 (epithelial) ( 3 ) , breast ( 1 ) , platelet-blood ( 3 )

Upstream Regulation
Treatments:	colforsin ( 3 )

References
1	Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62 27251275 Curated Info
2	Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704 24719451 Curated Info
3	Subramanian H, et al. (2013) Phosphorylation of CalDAG-GEFI by protein kinase A prevents Rap1b activation. J Thromb Haemost 11, 1574-82 23611601 Curated Info
4	Ruse CI, et al. (2008) Motif-specific sampling of phosphoproteomes. J Proteome Res 7, 2140-50 18452278 Curated Info