Ser587
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Home > Phosphorylation Site Page: > Ser587  -  RASGRP2 (human)

Site Information
PRPGRrGsRPPEIRE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 10993875

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 , 3 , 4 ) , mutation of modification site ( 2 ) , phospho-antibody ( 2 ) , western blotting ( 2 )
Disease tissue studied:
HER2 positive breast cancer ( 1 ) , luminal A breast cancer ( 1 ) , luminal B breast cancer ( 1 ) , breast cancer, triple negative ( 1 ) , acute monoblastic leukemia (M5a) or acute monocytic leukemia (M5b) ( 4 ) , acute myeloblastic leukemia, without maturation (M1) ( 4 ) , B cell lymphoma ( 4 ) , non-Hodgkin's lymphoma ( 4 ) , multiple myeloma ( 4 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 2 ) , breast ( 1 ) , CTS (myeloid) ( 4 ) , DOHH2 ('B lymphocyte, precursor') ( 4 ) , Jurkat (T lymphocyte) ( 3 ) , MV4-11 (macrophage) ( 4 ) , OPM-2 (plasma cell) ( 4 ) , P31/FUJ (erythroid) ( 4 ) , platelet-blood ( 2 ) , RL ('B lymphocyte, precursor') ( 4 ) , RPMI-8226 (plasma cell) ( 4 ) , SU-DHL-6 (B lymphocyte) ( 4 ) , U266 (plasma cell) ( 4 )

Upstream Regulation
Putative in vivo kinases:
PKACA (human) ( 2 )
Treatments:
8-Rp-cAMP ( 2 ) , A23187 ( 2 ) , alprostadil ( 2 ) , colforsin ( 2 ) , thrombin ( 2 )

References 

1

Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62
27251275   Curated Info

2

Subramanian H, et al. (2013) Phosphorylation of CalDAG-GEFI by protein kinase A prevents Rap1b activation. J Thromb Haemost 11, 1574-82
23611601   Curated Info

3

Mertins P, et al. (2013) Integrated proteomic analysis of post-translational modifications by serial enrichment. Nat Methods 10, 634-7
23749302   Curated Info

4

Casado P, et al. (2013) Phosphoproteomics data classify hematological cancer cell lines according to tumor type and sensitivity to kinase inhibitors. Genome Biol 14, R37
23628362   Curated Info