Tyr284
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Home > Phosphorylation Site Page: > Tyr284  -  CLCN3 iso2 (rat)

Site Information
FSLEEVSyYFPLKTL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 3577859

In vivo Characterization
Methods used to characterize site in vivo:
flow cytometry ( 3 ) , immunoprecipitation ( 2 , 3 ) , mutation of modification site ( 1 , 2 , 3 ) , western blotting ( 3 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
ITGB3 (human) ( 2 )
Putative in vivo kinases:
Src (human) ( 2 , 3 )
Treatments:
angiotensin_2 ( 2 ) , hypertonic_buffer ( 2 )

Downstream Regulation
Effects of modification on CLCN3 iso2:
activity, induced ( 1 , 3 ) , molecular association, regulation ( 2 )
Effects of modification on biological processes:
apoptosis, inhibited ( 3 ) , signaling pathway regulation ( 2 )
Induce interaction with:
ITGB3 (human) ( 2 )

References 

1

Xu B, et al. (2015) Chloride channel-3 promotes tumor metastasis by regulating membrane ruffling and is associated with poor survival. Oncotarget 6, 2434-50
25537517   Curated Info

2

Zeng JW, et al. (2014) Integrin β3 mediates cerebrovascular remodelling through Src/ClC-3 volume-regulated Cl(-) channel signalling pathway. Br J Pharmacol 171, 3158-70
24611720   Curated Info

3

Wang XG, et al. (2013) Tyrosine 284 phosphorylation is required for ClC-3 chloride channel activation in vascular smooth muscle cells. Cardiovasc Res 98, 469-78
23536605   Curated Info