Lys559
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Home > Sumoylation Site Page: > Lys559  -  HDAC4 (human)

Site Information
AQAGVQVkQEPIEsD   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 2793919

In vivo Characterization
Methods used to characterize site in vivo:
electrophoretic mobility shift ( 3 ) , mutation of modification site ( 1 , 3 ) , western blotting ( 3 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
CAMK1A (human) ( 3 ) , PIAS1 (human) ( 3 ) , PIAS3 (human) ( 3 )

Downstream Regulation
Effects of modification on HDAC4:
acetylation ( 3 ) , enzymatic activity, induced ( 3 ) , protein degradation ( 1 ) , ubiquitination ( 1 )
Effects of modification on biological processes:
apoptosis, inhibited ( 1 ) , transcription, inhibited ( 3 )

References 

1

Du J, et al. (2015) HDAC4 Degradation Mediates HDAC Inhibition-Induced Protective Effects Against Hypoxia/Reoxygenation Injury. J Cell Physiol 230, 1321-31
25475100   Curated Info

2

Impens F, Radoshevich L, Cossart P, Ribet D (2014) Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli. Proc Natl Acad Sci U S A 111, 12432-7
25114211   Curated Info

3

Kirsh O, et al. (2002) The SUMO E3 ligase RanBP2 promotes modification of the HDAC4 deacetylase. EMBO J 21, 2682-91
12032081   Curated Info