Tyr488
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Home > Phosphorylation Site Page: > Tyr488  -  CEACAM1 (mouse)

Site Information
NKVDDVAyTVLNFNs   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447777

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 2 ) , immunoprecipitation ( 2 ) , mutation of modification site ( 1 , 2 , 3 ) , phospho-antibody ( 3 ) , western blotting ( 2 )
Disease tissue studied:
colorectal cancer ( 3 ) , colorectal carcinoma ( 3 )
Relevant cell line - cell type - tissue:
3T3 (fibroblast) ( 2 ) , CT51 (intestinal) ( 3 ) , hepatocyte-liver ( 2 ) , MDCK (epithelial) ( 1 )

Upstream Regulation
Treatments:
insulin ( 2 ) , vanadate ( 3 )

Downstream Regulation
Effects of modification on CEACAM1:
intracellular localization ( 1 ) , molecular association, regulation ( 2 , 3 )
Effects of modification on biological processes:
cell growth, altered ( 2 )
Induce interaction with:
SHC1 (mouse) ( 2 ) , SHP-2 (mouse) ( 3 )

References 

1

Sundberg U, Beauchemin N, Obrink B (2004) The cytoplasmic domain of CEACAM1-L controls its lateral localization and the organization of desmosomes in polarized epithelial cells. J Cell Sci 117, 1091-104
14970258   Curated Info

2

Poy MN, et al. (2002) Shc and CEACAM1 interact to regulate the mitogenic action of insulin. J Biol Chem 277, 1076-84
11694516   Curated Info

3

Huber M, et al. (1999) The carboxyl-terminal region of biliary glycoprotein controls its tyrosine phosphorylation and association with protein-tyrosine phosphatases SHP-1 and SHP-2 in epithelial cells. J Biol Chem 274, 335-44
9867848   Curated Info