Ser554

Site Information
sIRPRPGsLRSkPEP SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 458238

In vivo Characterization
Methods used to characterize site in vivo:	[32P] bio-synthetic labeling ( 5 ) , mass spectrometry ( 2 , 3 , 4 , 5 ) , mutation of modification site ( 1 , 5 )
Disease tissue studied:	HER2 positive breast cancer ( 2 ) , luminal A breast cancer ( 2 ) , luminal B breast cancer ( 2 ) , breast cancer, triple negative ( 2 )
Relevant cell line - cell type - tissue:	breast ( 2 ) , HeLa (cervical) ( 1 , 5 ) , Jurkat (T lymphocyte) ( 3 , 4 )

Downstream Regulation
Effects of modification on CENTB1:	molecular association, regulation ( 5 )
Effects of modification on biological processes:	cell motility, altered ( 5 )
Induce interaction with:	ITGB1 (human) ( 5 )

References
1	Hsu JW, et al. (2020) The protein kinase Akt acts as a coat adaptor in endocytic recycling. Nat Cell Biol 32541877 Curated Info
2	Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62 27251275 Curated Info
3	Mulhern D (2012) CST Curation Set: 13828; Year: 2012; Biosample/Treatment: cell line, Jurkat/calyculin_A & pervanadate; Disease: T cell leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: (K/R)XpSX(K/R) Curated Info
4	Guo A (2011) CST Curation Set: 12059; Year: 2011; Biosample/Treatment: cell line, Jurkat/calyculin_A & pervanadate; Disease: T cell leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pTXR Curated Info
5	Li J, et al. (2005) Phosphorylation of ACAP1 by Akt regulates the stimulation-dependent recycling of integrin beta1 to control cell migration. Dev Cell 9, 663-73 16256741 Curated Info