Ser204
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Home > Phosphorylation Site Page: > Ser204  -  Claudin-7 (human)

Site Information
VPRsYPksNsskEyV   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 27732000

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 2 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Disease tissue studied:
lung cancer ( 1 , 2 ) , non-small cell lung cancer ( 1 , 2 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
PKCA (human) ( 1 )
Treatments:
bisindolylmaleimide ( 1 ) , chelerythrine ( 1 ) , lithium ( 1 ) , PD90059 ( 1 )

Downstream Regulation
Effects of modification on biological processes:
apoptosis, induced ( 1 )

References 

1

Hoggard J, et al. (2013) Claudin-7 increases chemosensitivity to cisplatin through the upregulation of caspase pathway in human NCI-H522 lung cancer cells. Cancer Sci 104, 611-8
23433123   Curated Info

2

Klammer M, et al. (2012) Phosphosignature predicts dasatinib response in non-small cell lung cancer. Mol Cell Proteomics 11, 651-68
22617229   Curated Info