Tyr791
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Home > Phosphorylation Site Page: > Tyr791  -  TrkA (human)

Site Information
LAQAPPVyLDVLG__   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447765

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 6 ) , mass spectrometry ( 1 , 2 ) , mutation of modification site ( 3 , 4 , 6 ) , phospho-antibody ( 4 , 5 ) , western blotting ( 4 , 5 , 6 )
Disease tissue studied:
adrenal cancer ( 5 , 6 ) , pheochromocytoma ( 5 , 6 ) , multiple myeloma ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Treatments:
EGF ( 6 ) , NGF ( 5 , 6 ) , vanadate ( 6 )

Downstream Regulation
Effects of modification on TrkA:
enzymatic activity, induced ( 4 , 5 , 6 ) , molecular association, regulation ( 6 )
Effects of modification on biological processes:
apoptosis, induced ( 4 ) , cell growth, altered ( 5 )
Induce interaction with:
PLCG1 (human) ( 6 )

References 

1

Goss V (2006) CST Curation Set: 1358; Year: 2006; Biosample/Treatment: cell line, XG5/serum starved &'||' IL6 starvation; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

2

Goss V (2005) CST Curation Set: 968; Year: 2005; Biosample/Treatment: tissue, blood/-; Disease: chronic lymphocytic leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

3

Rankin SL, Guy CS, Mearow KM (2005) TrkA NGF receptor plays a role in the modulation of p75NTR expression. Neurosci Lett 383, 305-10
15955426   Curated Info

4

Chou TT, Trojanowski JQ, Lee VM (2000) A novel apoptotic pathway induced by nerve growth factor-mediated TrkA activation in medulloblastoma. J Biol Chem 275, 565-70
10617652   Curated Info

5

Stephens RM, et al. (1994) Trk receptors use redundant signal transduction pathways involving SHC and PLC-gamma 1 to mediate NGF responses. Neuron 12, 691-705
8155326   Curated Info

6

Obermeier A, et al. (1993) Tyrosine 785 is a major determinant of Trk--substrate interaction. EMBO J 12, 933-41
8384556   Curated Info