Ser87
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Home > Phosphorylation Site Page: > Ser87  -  BIM (human)

Site Information
FIFMRRSsLLSRSss   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 458219

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 2 , 4 ) , mutation of modification site ( 5 )
Disease tissue studied:
lung cancer ( 2 ) , non-small cell lung adenocarcinoma ( 2 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Kinases, in vitro:
Akt1 (human) ( 5 )

Downstream Regulation
Effects of modification on biological processes:
apoptosis, altered ( 5 )

References 

1

Ghia EM, et al. (2019) Activation of Hedgehog signaling associates with early disease progression in chronic lymphocytic leukemia. Blood
30923040   Curated Info

2

Schweppe DK, Rigas JR, Gerber SA (2013) Quantitative phosphoproteomic profiling of human non-small cell lung cancer tumors. J Proteomics 91, 286-96
23911959   Curated Info

3

Shiromizu T, et al. (2013) Identification of missing proteins in the neXtProt database and unregistered phosphopeptides in the PhosphoSitePlus database as part of the Chromosome-centric Human Proteome Project. J Proteome Res 12, 2414-21
23312004   Curated Info

4

Moritz A (2008) CST Curation Set: 5780; Year: 2008; Biosample/Treatment: cell line, NCI-H3255/Iressa; Disease: non-small cell lung cancer; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: RRXp[ST] Antibodies Used to Purify Peptides prior to LCMS: Phospho-PKA Substrate (RRXS/T) (100G7) Rabbit mAb Cat#: 9624, PTMScan(R) Phospho-PKA Substrate Motif (K/RK/RXS*/T*) Immunoaffinity Beads Cat#: 1984
Curated Info

5

Qi XJ, Wildey GM, Howe PH (2006) Evidence that Ser87 of BimEL is phosphorylated by Akt and regulates BimEL apoptotic function. J Biol Chem 281, 813-23
16282323   Curated Info