Tyr1325
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Home > Phosphorylation Site Page: > Tyr1325  -  NMDAR2A (mouse)

Site Information
RLLEGNLyGsLFSVP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 458211
Associated spectra:  1 CST

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 , 4 , 5 ) , mutation of modification site ( 3 ) , phospho-antibody ( 3 ) , western blotting ( 3 )
Relevant cell line - cell type - tissue:
'brain, striatum' ( 3 ) , brain ( 4 , 5 ) , neuron:postsynaptic density-'brain, hippocampus, CA1 region' ( 1 )

Upstream Regulation
Treatments:
elevated plus maze test ( 3 ) , forced swim test ( 3 ) , long-term_potentiation ( 1 ) , open field test ( 3 ) , tail suspension test ( 3 )

Downstream Regulation
Effects of modification on NMDAR2A:
activity, induced ( 3 ) , phosphorylation ( 3 )

Disease / Diagnostics Relevance
Relevant diseases:
depression ( 3 )

References 

1

Li J, et al. (2016) Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome. Sci Signal 9, rs8
27507650   Curated Info

2

Nakai T, et al. (2014) Girdin Phosphorylation Is Crucial for Synaptic Plasticity and Memory: A Potential Role in the Interaction of BDNF/TrkB/Akt Signaling with NMDA Receptor. J Neurosci 34, 14995-5008
25378165   Curated Info

3

Taniguchi S, et al. (2009) Involvement of NMDAR2A tyrosine phosphorylation in depression-related behaviour. EMBO J 28, 3717-29
19834457   Curated Info

4

Zhou J (2008) CST Curation Set: 4322; Year: 2008; Biosample/Treatment: tissue, brain/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY
Curated Info

5

Guo A (2007) CST Curation Set: 2675; Year: 2007; Biosample/Treatment: tissue, brain/LY; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info