Ser1589
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Home > Phosphorylation Site Page: > Ser1589  -  talin 1 (mouse)

Site Information
SSVPAQIsPEGRAAM   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 27533485

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 2 , 3 ) , mass spectrometry (in vitro) ( 1 ) , mutation of modification site ( 1 )
Disease tissue studied:
anthrax infection ( 3 ) , bone cancer ( 1 )
Relevant cell line - cell type - tissue:
spleen ( 3 ) , stromal ( 2 ) , U2OS (bone cell) ( 1 )

Upstream Regulation
Kinases, in vitro:
CDK1 (mouse) ( 1 )

Downstream Regulation
Effects of modification on talin 1:
molecular association, regulation ( 1 ) , protein conformation ( 1 )
Inhibit interaction with:
ANKRD15 (mouse) ( 1 )

References 

1

Gough RE, et al. (2021) Talin mechanosensitivity is modulated by a direct interaction with cyclin-dependent kinase-1. J Biol Chem 297, 100837
34118235   Curated Info

2

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

3

Manes NP, et al. (2011) Discovery of mouse spleen signaling responses to anthrax using label-free quantitative phosphoproteomics via mass spectrometry. Mol Cell Proteomics 10, M110.000927
21189417   Curated Info