Thr337
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Home > Phosphorylation Site Page: > Thr337  -  ELK1 (mouse)

Site Information
GGQGPERtPGSGTSS   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 2751400

In vivo Characterization
Methods used to characterize site in vivo:
2D analysis ( 2 ) , [32P] bio-synthetic labeling ( 2 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 1 ) , phosphopeptide mapping ( 2 )
Relevant cell line - cell type - tissue:
3T3 (fibroblast) ( 2 ) , MEF (fibroblast) [ELK1 (mouse), homozygous knockout] ( 1 ) , MEF (fibroblast) ( 1 )

Upstream Regulation
Kinases, in vitro:
ERK1 (mouse) ( 2 ) , ERK2 (human) ( 1 )
Treatments:
phorbol_ester ( 1 )

Downstream Regulation
Effects of modification on ELK1:
molecular association, regulation ( 1 )
Effects of modification on biological processes:
transcription, inhibited ( 1 )
Inhibit interaction with:
MED16 (mouse) ( 1 ) , MED23 (mouse) ( 1 ) , Trap100 (mouse) ( 1 )

References 

1

Mylona A, et al. (2016) Opposing effects of Elk-1 multisite phosphorylation shape its response to ERK activation. Science 354, 233-237
27738173   Curated Info

2

Gille H, et al. (1995) ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation. EMBO J 14, 951-62
7889942   Curated Info

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