Lys50
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Home > Sumoylation Site Page: > Lys50  -  TR-beta1 (human)

Site Information
SERRSTLkNEQSsPH   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 27490401

In vivo Characterization
Methods used to characterize site in vivo:
electrophoretic mobility shift ( 1 , 3 ) , immunoprecipitation ( 1 , 3 ) , modification-specific antibody ( 1 , 3 ) , mutation of modification site ( 2 , 3 ) , western blotting ( 1 , 3 )
Disease tissue studied:
liver cancer ( 1 , 3 )
Relevant cell line - cell type - tissue:
3T3 (fibroblast) ( 2 ) , adipocyte ( 2 ) , adipose tissue ( 3 ) , C2C12 (myoblast) ( 3 ) , GH3 (epithelial) ( 3 ) , heart ( 3 ) , HepG2 (hepatic) ( 1 , 3 ) , liver ( 3 )

Upstream Regulation
Treatments:
liothyronine ( 3 )

Downstream Regulation
Effects of modification on TR-beta1:
intracellular localization ( 3 ) , molecular association, regulation ( 1 , 3 )
Effects of modification on biological processes:
cell differentiation, induced ( 2 ) , cell growth, induced ( 2 ) , signaling pathway regulation ( 2 ) , transcription, altered ( 1 , 3 ) , transcription, induced ( 2 )
Induce interaction with:
DNA ( 3 ) , N-CoR1 (human) ( 1 , 3 ) , Src (human) ( 1 )
Inhibit interaction with:
CBP (human) ( 3 ) , DNA ( 1 )

References 

1

Weitzel JM (2016) Impaired Repressor Function in SUMOylation-Defective Thyroid Hormone Receptor Isoforms. Eur Thyroid J 5, 152-163
27843805   Curated Info

2

Liu YY, et al. (2015) Thyroid hormone receptor sumoylation is required for preadipocyte differentiation and proliferation. J Biol Chem 290, 7402-15
25572392   Curated Info

3

Liu YY, et al. (2012) Thyroid hormone receptor isoform-specific modification by small ubiquitin-like modifier (SUMO) modulates thyroid hormone-dependent gene regulation. J Biol Chem 287, 36499-508
22930759   Curated Info