Ser2477

Site Information
KEPFPPssPLQkGGS SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 27458022

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 1 , 2 , 3 , 4 , 6 , 7 )
Disease tissue studied:	neuroblastoma ( 7 ) , melanoma skin cancer ( 2 )
Relevant cell line - cell type - tissue:	HeLa (cervical) ( 3 , 6 ) , HUVEC (endothelial) ( 1 ) , NB10 (neural crest) ( 7 ) , NPC (neural crest) ( 7 ) , SH-SY5Y (neural crest) ( 4 ) , WM239A (melanocyte) ( 2 )

Upstream Regulation
Treatments:	selumetinib ( 2 ) , vemurafenib ( 2 )

References
1	Daniel AE, et al. (2023) Serine phosphorylation of the RhoGEF Trio stabilizes endothelial cell-cell junctions. Small GTPases 14, 45-54 37528624 Curated Info
2	Stuart SA, et al. (2015) A Phosphoproteomic Comparison of B-RAFV600E and MKK1/2 Inhibitors in Melanoma Cells. Mol Cell Proteomics 14, 1599-615 25850435 Curated Info
3	Sharma K, et al. (2014) Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling. Cell Rep 8, 1583-94 25159151 Curated Info
4	Luerman GC, et al. (2014) Phosphoproteomic evaluation of pharmacological inhibition of leucine-rich repeat kinase 2 reveals significant off-target effects of LRRK-2-IN-1. J Neurochem 128, 561-76 24117733 Curated Info
5	Shiromizu T, et al. (2013) Identification of missing proteins in the neXtProt database and unregistered phosphopeptides in the PhosphoSitePlus database as part of the Chromosome-centric Human Proteome Project. J Proteome Res 12, 2414-21 23312004 Curated Info
6	Zhou H, et al. (2013) Toward a comprehensive characterization of a human cancer cell phosphoproteome. J Proteome Res 12, 260-71 23186163 Curated Info
7	DeNardo BD, et al. (2013) Quantitative phosphoproteomic analysis identifies activation of the RET and IGF-1R/IR signaling pathways in neuroblastoma. PLoS One 8, e82513 24349301 Curated Info
8	Beli P, et al. (2012) Proteomic Investigations Reveal a Role for RNA Processing Factor THRAP3 in the DNA Damage Response. Mol Cell 46, 212-25 22424773 Curated Info