Ser1791
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Home > Phosphorylation Site Page: > Ser1791  -  Notch 1 (human)

Site Information
REPLGEDsVGLkPLK   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 27457604

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 2 ) , mutation of modification site ( 1 )
Disease tissue studied:
cancer, squamous cell carcinoma ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
PLK1 (human) ( 1 )
Kinases, in vitro:
PLK1 (human) ( 1 )
Treatments:
adriamycin ( 1 ) , arsenite ( 1 ) , BI2536 ( 1 ) , hydroxyurea ( 1 ) , Ro3280 ( 1 )

Downstream Regulation
Effects of modification on Notch 1:
protein degradation ( 1 )
Effects of modification on biological processes:
cell cycle regulation ( 1 )

References 

1

De Blasio C, et al. (2019) PLK1 targets NOTCH1 during DNA damage and mitotic progression. J Biol Chem
31597699   Curated Info

2

Bian Y, et al. (2014) An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics 96, 253-62
24275569   Curated Info

3

Shiromizu T, et al. (2013) Identification of missing proteins in the neXtProt database and unregistered phosphopeptides in the PhosphoSitePlus database as part of the Chromosome-centric Human Proteome Project. J Proteome Res 12, 2414-21
23312004   Curated Info