Thr896
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Home > Phosphorylation Site Page: > Thr896  -  FANCD2 (human)

Site Information
kNsECDPtPsHRGQL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 27448950

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 1 , 2 , 3 ) , mutation of modification site ( 1 )
Disease tissue studied:
cervical cancer ( 1 ) , cervical adenocarcinoma ( 1 ) , melanoma skin cancer ( 2 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
CK2A1 (human) ( 1 )
Kinases, in vitro:
CK2A1 (human) ( 1 )
Treatments:
silmitasertib ( 1 )

Downstream Regulation
Effects of modification on FANCD2:
activity, inhibited ( 1 ) , intracellular localization ( 1 ) , molecular association, regulation ( 1 ) , ubiquitination ( 1 )
Effects of modification on biological processes:
cell cycle regulation ( 1 ) , DNA repair, inhibited ( 1 ) , signaling pathway regulation ( 1 )
Inhibit interaction with:
DNA ( 1 )

References 

1

Lopez-Martinez D, et al. (2019) Phosphorylation of FANCD2 Inhibits the FANCD2/FANCI Complex and Suppresses the Fanconi Anemia Pathway in the Absence of DNA Damage. Cell Rep 27, 2990-3005.e5
31167143   Curated Info

2

Stuart SA, et al. (2015) A Phosphoproteomic Comparison of B-RAFV600E and MKK1/2 Inhibitors in Melanoma Cells. Mol Cell Proteomics 14, 1599-615
25850435   Curated Info

3

Sharma K, et al. (2014) Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling. Cell Rep 8, 1583-94
25159151   Curated Info

4

Shiromizu T, et al. (2013) Identification of missing proteins in the neXtProt database and unregistered phosphopeptides in the PhosphoSitePlus database as part of the Chromosome-centric Human Proteome Project. J Proteome Res 12, 2414-21
23312004   Curated Info