Ser533
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Home > Phosphorylation Site Page: > Ser533  -  DLK (mouse)

Site Information
RNVPQKLsPHSKRPD   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 27447446

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 ) , mass spectrometry (in vitro) ( 2 ) , mutation of modification site ( 2 ) , phospho-antibody ( 2 ) , western blotting ( 2 )
Relevant cell line - cell type - tissue:
HEK293T (epithelial) ( 2 ) , neuron-dorsal root ganglia ( 2 ) , retinal ganglion ( 2 )

Upstream Regulation
Putative in vivo kinases:
JNK2 (mouse) ( 2 ) , JNK3 (mouse) ( 2 )
Kinases, in vitro:
JNK2 (mouse) ( 2 ) , JNK3 (mouse) ( 2 )
Treatments:
JNK_inhibitor_VIII ( 2 ) , siRNA ( 2 )

Downstream Regulation
Effects of modification on DLK:
protein stabilization ( 2 )

References 

1

Sacco F, et al. (2016) Glucose-regulated and drug-perturbed phosphoproteome reveals molecular mechanisms controlling insulin secretion. Nat Commun 7, 13250
27841257   Curated Info

2

Huntwork-Rodriguez S, et al. (2013) JNK-mediated phosphorylation of DLK suppresses its ubiquitination to promote neuronal apoptosis. J Cell Biol 202, 747-63
23979718   Curated Info