Ser106

Site Information
DHLRkEAsDPQPEEA SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 27445584

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 1 , 2 , 3 , 5 ) , mass spectrometry (in vitro) ( 1 ) , mutation of modification site ( 1 )
Disease tissue studied:	HER2 positive breast cancer ( 2 ) , luminal A breast cancer ( 2 ) , luminal B breast cancer ( 2 ) , breast cancer, triple negative ( 2 ) , prostate cancer ( 1 )
Relevant cell line - cell type - tissue:	breast ( 2 ) , DU 145 (prostate cell) ( 1 ) , HeLa (cervical) ( 3 , 5 ) , LNCaP (prostate cell) ( 1 ) , PC3 (prostate cell) ( 1 )

Downstream Regulation
Effects of modification on biological processes:	cell adhesion, induced ( 1 ) , cell motility, induced ( 1 ) , cytoskeletal reorganization ( 1 )

References
1	Santio NM, et al. (2020) PIM1 accelerates prostate cancer cell motility by phosphorylating actin capping proteins. Cell Commun Signal 18, 121 32771000 Curated Info
2	Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62 27251275 Curated Info
3	Sharma K, et al. (2014) Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling. Cell Rep 8, 1583-94 25159151 Curated Info
4	Shiromizu T, et al. (2013) Identification of missing proteins in the neXtProt database and unregistered phosphopeptides in the PhosphoSitePlus database as part of the Chromosome-centric Human Proteome Project. J Proteome Res 12, 2414-21 23312004 Curated Info
5	Kettenbach AN, et al. (2011) Quantitative phosphoproteomics identifies substrates and functional modules of aurora and polo-like kinase activities in mitotic cells. Sci Signal 4, rs5 21712546 Curated Info