Ser574
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Home > Phosphorylation Site Page: > Ser574  -  SEC63 (human)

Site Information
EEVsDKGsDsEEEET   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 27440601

In vivo Characterization
Methods used to characterize site in vivo:
[32P] ATP in vitro ( 2 ) , mass spectrometry ( 1 )
Disease tissue studied:
liver cancer ( 2 )
Relevant cell line - cell type - tissue:
HepG2 (hepatic) ( 2 ) , liver ( 1 )

Upstream Regulation
Putative in vivo kinases:
CK2A1 (human) ( 2 ) , CK2B (human) ( 2 )
Kinases, in vitro:
CK2A1 (human) ( 2 ) , CK2B (human) ( 2 )

Downstream Regulation
Effects of modification on SEC63:
molecular association, regulation ( 2 )
Induce interaction with:
SEC62 (human) ( 2 )

References 

1

Bian Y, et al. (2014) An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics 96, 253-62
24275569   Curated Info

2

Ampofo E, et al. (2013) CK2 phosphorylation of human Sec63 regulates its interaction with Sec62. Biochim Biophys Acta 1830, 2938-45
23287549   Curated Info