Ser571
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Home > Phosphorylation Site Page: > Ser571  -  SCN5A (mouse)

Site Information
PWPLRRPsTQGQPGF   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 27281507

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 6 ) , mass spectrometry ( 2 , 6 ) , mutation of modification site ( 3 ) , phospho-antibody ( 5 ) , western blotting ( 2 , 5 )
Relevant cell line - cell type - tissue:
heart ( 6 ) , myocardium ( 5 ) , myocyte-heart ( 3 )

Upstream Regulation
Treatments:
pressure ( 5 )

Downstream Regulation
Effects of modification on SCN5A:
activity, induced ( 3 )

References 

1

Howard T, et al. (2018) CaMKII-dependent late sodium current increases electrical dispersion and arrhythmia in ischemia/reperfusion. Am J Physiol Heart Circ Physiol
29932771   Curated Info

2

Burel S, et al. (2017) C-terminal phosphorylation of NaV1.5 impairs FGF13-dependent regulation of channel inactivation. J Biol Chem 292, 17431-17448
28882890   Curated Info

3

Glynn P, et al. (2015) Voltage-Gated Sodium Channel Phosphorylation at Ser571 Regulates Late Current, Arrhythmia, and Cardiac Function In Vivo. Circulation 132, 567-77
26187182   Curated Info

4

Dybkova N, et al. (2014) Tubulin polymerization disrupts cardiac β-adrenergic regulation of late INa. Cardiovasc Res 103, 168-77
24812278   Curated Info

5

Toischer K, et al. (2013) Role of late sodium current as a potential arrhythmogenic mechanism in the progression of pressure-induced heart disease. J Mol Cell Cardiol 61, 111-22
23570977   Curated Info

6

Marionneau C, et al. (2012) Mass Spectrometry-Based Identification of Native Cardiac Nav1.5 Channel α Subunit Phosphorylation Sites. J Proteome Res 11, 5994-6007
23092124   Curated Info