Ser506
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Home > Phosphorylation Site Page: > Ser506  -  TOP1 (human)

Site Information
ADTVGCCsLRVEHIN   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 27276101

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 ) , mutation of modification site ( 2 , 3 ) , phospho-antibody ( 1 , 2 , 3 ) , western blotting ( 1 , 2 , 3 )
Disease tissue studied:
colorectal cancer ( 1 ) , colorectal carcinoma ( 1 ) , lung cancer ( 1 , 2 , 3 ) , non-small cell lung cancer ( 1 , 2 , 3 ) , ovarian cancer ( 1 , 3 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Kinases, in vitro:
CK2A1 (human) ( 2 , 3 )
Treatments:
camptothecin ( 1 ) , CK2_activator ( 3 ) , CK2_inhibitor ( 3 ) , TBB ( 2 )

Downstream Regulation
Effects of modification on TOP1:
molecular association, regulation ( 2 , 3 )
Induce interaction with:
ARF1 (human) ( 2 ) , DNA ( 2 , 3 )

Disease / Diagnostics Relevance
Relevant diseases:
colorectal carcinoma ( 1 ) , non-small cell lung adenocarcinoma, surrounding tissue ( 1 ) , ovarian cancer ( 1 )

References 

1

Zhao M, Gjerset RA (2015) Topoisomerase-I PS506 as a Dual Function Cancer Biomarker. PLoS One 10, e0134929
26248194   Curated Info

2

Bandyopadhyay K, Li P, Gjerset RA (2013) The p14ARF Alternate Reading Frame Protein Enhances DNA Binding of Topoisomerase I by Interacting with the Serine 506-Phosphorylated Core Domain. PLoS One 8, e58835
23555599   Curated Info

3

Bandyopadhyay K, Li P, Gjerset RA (2012) CK2-Mediated Hyperphosphorylation of Topoisomerase I Targets Serine 506, Enhances Topoisomerase I-DNA Binding, and Increases Cellular Camptothecin Sensitivity. PLoS One 7, e50427
23185622   Curated Info