Ser92
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Home > Phosphorylation Site Page: > Ser92  -  MCU (human)

Site Information
VISVRLPsRRERCQF   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 27259017

In vivo Characterization
Methods used to characterize site in vivo:
[32P] ATP in vitro ( 1 ) , immunoprecipitation ( 2 ) , mutation of modification site ( 1 , 2 )
Relevant cell line - cell type - tissue:
E.coli (bacterial) ( 1 ) , HeLa (cervical) ( 2 )

Upstream Regulation
Kinases, in vitro:
PKCB iso2 (human) ( 1 ) , PKCD (human) ( 1 ) , PKCE (human) ( 1 )

Downstream Regulation
Effects of modification on MCU:
molecular association, regulation ( 1 ) , protein conformation ( 1 , 2 )
Inhibit interaction with:
MCU (human) ( 1 )

References 

1

Lee Y, et al. (2020) S92 phosphorylation induces structural changes in the N-terminus domain of human mitochondrial calcium uniporter. Sci Rep 10, 9131
32499574   Curated Info

2

Lee Y, et al. (2015) Structure and function of the N-terminal domain of the human mitochondrial calcium uniporter. EMBO Rep 16, 1318-33
26341627   Curated Info