Lys379
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Home > Ubiquitylation Site Page: > Lys379  -  STAT1 (mouse)

Site Information
NTVKGFRkFNILGTH   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 27211085

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 1 ) , immunoprecipitation ( 1 ) , mass spectrometry ( 2 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Disease tissue studied:
fibrosarcoma of soft tissue ( 1 )
Relevant cell line - cell type - tissue:
L929 (fibroblast) ( 1 ) , liver ( 2 ) , pooled tissues ( 2 ) , RAW 267.4 (macrophage) ( 1 )

Upstream Regulation
Treatments:
IFN-beta ( 1 ) , siRNA ( 1 )

Downstream Regulation
Effects of modification on STAT1:
molecular association, regulation ( 1 )
Effects of modification on biological processes:
transcription, inhibited ( 1 )
Inhibit interaction with:
DNA ( 1 )

References 

1

Liu S, et al. (2018) Nuclear RNF2 inhibits interferon function by promoting K33-linked STAT1 disassociation from DNA. Nat Immunol 19, 41-52
29242538   Curated Info

2

Wagner SA, et al. (2012) Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Mol Cell Proteomics 11, 1578-85
22790023   Curated Info

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