Lys3
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Home > Ubiquitylation Site Page: > Lys3  -  PLB (mouse)

Site Information
_____MEkVQYLTRS   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 27204320

In vivo Characterization
Methods used to characterize site in vivo:
electrophoretic mobility shift ( 1 ) , mass spectrometry ( 2 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 1 ) , heart ( 2 ) , pooled tissues ( 2 )

Upstream Regulation
Regulatory protein:
PLB (human) ( 1 )
Treatments:
isoproterenol ( 1 ) , MG132 ( 1 )

Downstream Regulation
Effects of modification on PLB:
ubiquitination ( 1 )

References 

1

Nakagawa T, Yokoe S, Asahi M (2016) Phospholamban degradation is induced by phosphorylation-mediated ubiquitination and inhibited by interaction with cardiac type Sarco(endo)plasmic reticulum Ca(2+)-ATPase. Biochem Biophys Res Commun 472, 523-30
26966065   Curated Info

2

Wagner SA, et al. (2012) Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Mol Cell Proteomics 11, 1578-85
22790023   Curated Info

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