Lys123

Site Information
FsPGPGIkEESVPLS SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 2715401

In vivo Characterization
Methods used to characterize site in vivo:	immunoprecipitation ( 1 , 2 ) , mutation of modification site ( 1 , 2 ) , western blotting ( 1 , 2 )
Disease tissue studied:	liver cancer ( 1 )
Relevant cell line - cell type - tissue:	293 (epithelial) ( 2 ) , CHO (fibroblast) ( 2 ) , COS (fibroblast) ( 1 , 2 ) , HEK293T (epithelial) ( 1 ) , HeLa (cervical) ( 2 ) , HepG2 (hepatic) ( 1 )

Downstream Regulation
Effects of modification on biological processes:	transcription, inhibited ( 2 )

References
1	Arito M, et al. (2008) Growth factor-induced phosphorylation of sterol regulatory element-binding proteins inhibits sumoylation, thereby stimulating the expression of their target genes, low density lipoprotein uptake, and lipid synthesis. J Biol Chem 283, 15224-31 18403372 Curated Info
2	Hirano Y, et al. (2003) Sterol regulatory element-binding proteins are negatively regulated through SUMO-1 modification independent of the ubiquitin/26 S proteasome pathway. J Biol Chem 278, 16809-19 12615929 Curated Info