Lys464
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Home > Sumoylation Site Page: > Lys464  -  SREBP-2 (human)

Site Information
LLDDAKVkDEPDSPP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 2715400

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 , 2 ) , mutation of modification site ( 1 , 2 ) , western blotting ( 1 , 2 )
Disease tissue studied:
liver cancer ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Treatments:
IGF-1 ( 1 ) , N-ethylmaleimede ( 1 ) , U0126 ( 1 )

Downstream Regulation
Effects of modification on SREBP-2:
molecular association, regulation ( 1 )
Effects of modification on biological processes:
transcription, inhibited ( 1 , 2 )
Induce interaction with:
HDAC3 (human) ( 1 )

References 

1

Arito M, et al. (2008) Growth factor-induced phosphorylation of sterol regulatory element-binding proteins inhibits sumoylation, thereby stimulating the expression of their target genes, low density lipoprotein uptake, and lipid synthesis. J Biol Chem 283, 15224-31
18403372   Curated Info

2

Hirano Y, et al. (2003) Sterol regulatory element-binding proteins are negatively regulated through SUMO-1 modification independent of the ubiquitin/26 S proteasome pathway. J Biol Chem 278, 16809-19
12615929   Curated Info