Ser25
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Home > Phosphorylation Site Page: > Ser25  -  RIPK1 (human)

Site Information
LEsAELDsGGFGKVs   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 27116402

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 2 , 3 , 4 ) , mass spectrometry (in vitro) ( 1 ) , mutation of modification site ( 1 )
Disease tissue studied:
breast cancer ( 3 ) , breast ductal carcinoma ( 3 ) , HER2 positive breast cancer ( 2 ) , luminal A breast cancer ( 2 ) , luminal B breast cancer ( 2 ) , breast cancer, triple negative ( 2 ) , colorectal cancer ( 1 ) , colorectal carcinoma ( 1 ) , leukemia ( 4 ) , T cell leukemia ( 4 )
Relevant cell line - cell type - tissue:
breast ( 2 , 3 ) , HEK293T (epithelial) ( 1 ) , HT-29 (intestinal) ( 1 ) , Jurkat (T lymphocyte) ( 4 )

Upstream Regulation
Putative upstream phosphatases:
PPP1CC (human) ( 1 )
Phosphatases, in vitro:
PPP1CC (human) ( 1 )
Treatments:
siRNA ( 1 )

Downstream Regulation
Effects of modification on RIPK1:
enzymatic activity, inhibited ( 1 ) , molecular association, regulation ( 1 ) , phosphorylation ( 1 )
Effects of modification on biological processes:
apoptosis, inhibited ( 1 )
Induce interaction with:
CASP8 (human) ( 1 ) , FADD (human) ( 1 )

References 

1

Du J, et al. (2021) RIPK1 dephosphorylation and kinase activation by PPP1R3G/PP1γ promote apoptosis and necroptosis. Nat Commun 12, 7067
34862394   Curated Info

2

Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62
27251275   Curated Info

3

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

4

Degterev A, et al. (2008) Identification of RIP1 kinase as a specific cellular target of necrostatins. Nat Chem Biol 4, 313-21
18408713   Curated Info

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