Ser400
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Home > Phosphorylation Site Page: > Ser400  -  Cot (human)

Site Information
EDQPRCQsLDSALLE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447712

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 2 ) , mass spectrometry ( 1 ) , mutation of modification site ( 2 ) , phosphopeptide mapping ( 2 )
Disease tissue studied:
HER2 positive breast cancer ( 1 ) , luminal A breast cancer ( 1 ) , luminal B breast cancer ( 1 ) , breast cancer, triple negative ( 1 )
Relevant cell line - cell type - tissue:
breast ( 1 ) , Jurkat (T lymphocyte) ( 2 )

Upstream Regulation
Kinases, in vitro:
Akt1 (human) ( 2 )

Downstream Regulation
Effects of modification on biological processes:
transcription, altered ( 2 )

References 

1

Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62
27251275   Curated Info

2

Kane LP, et al. (2002) Akt-dependent phosphorylation specifically regulates Cot induction of NF-kappa B-dependent transcription. Mol Cell Biol 22, 5962-74
12138205   Curated Info