Ser323
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Home > Phosphorylation Site Page: > Ser323  -  DUSP1 (human)

Site Information
HCSAEAGsPAMAVLD   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 457718

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
ERK2 (human) ( 1 )
Kinases, in vitro:
ERK2 (human) ( 1 )
Treatments:
serum ( 1 ) , U0126 ( 1 )

Downstream Regulation
Effects of modification on DUSP1:
molecular association, regulation ( 1 ) , protein degradation ( 1 )
Induce interaction with:
SKP2 (human) ( 1 )

References 

1

Lin YW, Yang JL (2006) Cooperation of ERK and SCFSkp2 for MKP-1 destruction provides a positive feedback regulation of proliferating signaling. J Biol Chem 281, 915-26
16286470   Curated Info