Tyr287

Site Information
LSPPRSDyWAMLAYN SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 457684

In vivo Characterization
Methods used to characterize site in vivo:	immunoprecipitation ( 1 ) , phospho-antibody ( 2 ) , western blotting ( 1 , 2 )
Disease tissue studied:	leukemia ( 1 ) , T cell leukemia ( 1 )
Relevant cell line - cell type - tissue:	COS7 (fibroblast) ( 2 ) , Jurkat (T lymphocyte) ( 1 ) , MOLT-4 (T lymphocyte) ( 1 ) , T-ALL (T lymphocyte) ( 1 )

Upstream Regulation
Treatments:	A23187 ( 1 ) , cold_shock ( 2 ) , phorbol_ester ( 1 ) , UV ( 2 )

References
1	Huang SS, et al. (2016) Role of WW Domain-containing Oxidoreductase WWOX in Driving T Cell Acute Lymphoblastic Leukemia Maturation. J Biol Chem 291, 17319-31 27339895 Curated Info
2	Chen SJ, et al. (2015) UV irradiation/cold shock-mediated apoptosis is switched to bubbling cell death at low temperatures. Oncotarget 6, 8007-18 25779665 Curated Info