Ser367
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Home > Phosphorylation Site Page: > Ser367  -  MDM4 (mouse)

Site Information
PDCRRtIsAPVVRPK   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 457676

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 5 , 6 ) , mass spectrometry ( 4 ) , mutation of modification site ( 2 , 3 , 5 ) , phospho-antibody ( 3 , 5 , 6 ) , western blotting ( 2 , 3 , 5 , 6 )
Disease tissue studied:
bone cancer ( 3 ) , neuroblastoma ( 4 )
Relevant cell line - cell type - tissue:
'neuron, cortical' ( 6 ) , MEF (fibroblast) ( 2 , 3 , 5 ) , N1E-115 (neuron) ( 4 ) , neuron-'brain, cerebellum' ( 6 ) , U2OS (bone cell) ( 3 )

Upstream Regulation
Putative in vivo kinases:
Chk1 (human) ( 3 )
Treatments:
anti-APP ( 6 ) , glutamic acid ( 6 ) , hypoxia ( 3 ) , ionizing_radiation ( 5 ) , low_potassium ( 6 ) , MG132 ( 5 ) , neocarzinostatin ( 5 , 6 ) , UCN-01 ( 3 )

Downstream Regulation
Effects of modification on MDM4:
molecular association, regulation ( 2 , 3 ) , protein degradation ( 5 , 6 )
Effects of modification on biological processes:
apoptosis, inhibited ( 6 ) , cell cycle regulation ( 2 ) , signaling pathway regulation ( 3 )
Induce interaction with:
14-3-3 gamma (human) ( 3 ) , 14-3-3 gamma (mouse) ( 2 )

References 

1

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

2

He G, et al. (2014) AMP-Activated Protein Kinase Induces p53 by Phosphorylating MDMX and Inhibiting Its Activity. Mol Cell Biol 34, 148-57
24190973   Curated Info

3

Lee JH, et al. (2012) Hypoxia Activates Tumor Suppressor p53 by Inducing ATR-Chk1 Kinase Cascade-mediated Phosphorylation and Consequent 14-3-3γ Inactivation of MDMX Protein. J Biol Chem 287, 20898-903
22556425   Curated Info

4

Wang Y, et al. (2011) Spatial phosphoprotein profiling reveals a compartmentalized extracellular signal-regulated kinase switch governing neurite growth and retraction. J Biol Chem 286, 18190-201
21454597   Curated Info

5

Wang YV, et al. (2009) Increased radioresistance and accelerated B cell lymphomas in mice with Mdmx mutations that prevent modifications by DNA-damage-activated kinases. Cancer Cell 16, 33-43
19573810   Curated Info

6

Benosman S, et al. (2007) Multiple neurotoxic stresses converge on MDMX proteolysis to cause neuronal apoptosis. Cell Death Differ 14, 2047-2057
17823617   Curated Info