Ser603
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Home > Phosphorylation Site Page: > Ser603  -  NHE3 (mouse)

Site Information
SLEQRRRsIRDTEDM   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450900

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 5 ) , phospho-antibody ( 1 , 2 , 4 ) , western blotting ( 1 , 2 , 4 )
Relevant cell line - cell type - tissue:
kidney ( 1 , 2 , 4 , 5 )

Upstream Regulation
Treatments:
alogliptin ( 4 ) , caffeine ( 2 ) , empagliflozin ( 1 ) , excendin-4 ( 4 ) , GLP-1 ( 4 )

References 

1

Onishi A, et al. (2020) A role for the tubular Na-H-exchanger NHE3 in the natriuretic effect of the SGLT2 inhibitor empagliflozin. Am J Physiol Renal Physiol
32893663   Curated Info

2

Fenton RA, et al. (2015) Caffeine-induced diuresis and natriuresis is independent of renal tubular NHE3. Am J Physiol Renal Physiol 308, F1409-20
25925253   Curated Info

3

Chen T, et al. (2015) Cyclic GMP kinase II (cGKII) inhibits NHE3 by altering its trafficking and phosphorylating NHE3 at three required sites: identification of a multifunctional phosphorylation site. J Biol Chem 290, 1952-65
25480791   Curated Info

4

Rieg T, et al. (2012) Natriuretic effect by exendin-4, but not the DPP-4 inhibitor alogliptin, is mediated via the GLP-1 receptor and preserved in obese type 2 diabetic mice. Am J Physiol Renal Physiol 303, F963-71
22832924   Curated Info

5

Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89
21183079   Curated Info