Ser110

Site Information
WGDGGDssPSNVVsK SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 455977

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 1 , 2 , 3 , 5 , 6 , 7 ) , phospho-antibody ( 4 ) , western blotting ( 4 )
Disease tissue studied:	brain cancer ( 4 ) , glioma ( 4 )
Relevant cell line - cell type - tissue:	'brain, brainstem' ( 2 ) , 'brain, cerebellum' ( 2 ) , 'brain, cerebral cortex' ( 2 ) , 'kidney, cortex' ( 3 ) , 'kidney, inner medulla' ( 6 , 7 ) , adipose tissue ( 2 ) , astrocyte ( 4 ) , blood ( 2 ) , C6 (glial) ( 4 ) , heart ( 2 ) , IEC-6 (epithelial) ( 1 ) , intestine ( 2 ) , kidney ( 2 ) , liver ( 2 , 5 ) , lung ( 2 ) , muscle ( 2 ) , pancreas ( 2 ) , spleen ( 2 ) , stomach ( 2 ) , testis ( 2 ) , thymus ( 2 )

Upstream Regulation
Treatments:	bisindolylmaleimide ( 4 ) , phorbol_ester ( 4 )

References
1	Courcelles M, et al. (2013) Phosphoproteome dynamics reveal novel ERK1/2 MAP kinase substrates with broad spectrum of functions. Mol Syst Biol 9, 669 23712012 Curated Info
2	Lundby A, et al. (2012) Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. Nat Commun 3, 876 22673903 Curated Info
3	Feric M, et al. (2011) Large-scale phosphoproteomic analysis of membrane proteins in renal proximal and distal tubule. Am J Physiol Cell Physiol 300, C755-70 21209370 Curated Info
4	Yasuda K, et al. (2011) PKC-dependent inhibition of CA(2+) -dependent exocytosis from astrocytes. Glia 59, 143-51 20967886 Curated Info
5	Deng WJ, et al. (2010) Proteome, phosphoproteome, and hydroxyproteome of liver mitochondria in diabetic rats at early pathogenic stages. Mol Cell Proteomics 9, 100-16 19700791 Curated Info
6	Hoffert JD, et al. (2007) An automated platform for analysis of phosphoproteomic datasets: application to kidney collecting duct phosphoproteins. J Proteome Res 6, 3501-8 17683130 Curated Info
7	Hoffert JD, et al. (2006) Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites. Proc Natl Acad Sci U S A 103, 7159-64 16641100 Curated Info