Tyr12
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Home > Phosphorylation Site Page: > Tyr12  -  GIRK1 (mouse)

Site Information
RRKFGDDyQVVTTSS   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 457610

In vivo Characterization
Methods used to characterize site in vivo:
phospho-antibody ( 1 , 2 , 3 ) , western blotting ( 3 )
Disease tissue studied:
pituitary cancer ( 3 )
Relevant cell line - cell type - tissue:
'neuron, dorsal horn'-spinal cord ( 3 ) , AtT20 (pituitary cell) [KOR-1 (mouse), transfection] ( 3 ) , brain ( 1 ) , neuron-brain ( 2 ) , sciatic nerve ( 3 )

Upstream Regulation
Regulatory protein:
GRK3 (mouse) ( 3 ) , KOR-1 (mouse) ( 3 ) , P38A (mouse) ( 1 , 2 )
Putative in vivo kinases:
Src iso1 (mouse) ( 3 )
Treatments:
norBNI ( 3 ) , PP2 ( 3 ) , SB203580 ( 3 ) , SNL ( 3 ) , swim stress ( 2 ) , U50488 ( 3 )

Downstream Regulation
Effects of modification on GIRK1:
activity, inhibited ( 1 , 3 )

References 

1

Ehrich JM, et al. (2015) Kappa Opioid Receptor-Induced Aversion Requires p38 MAPK Activation in VTA Dopamine Neurons. J Neurosci 35, 12917-31
26377476   Curated Info

2

Lemos JC, et al. (2012) Repeated stress dysregulates κ-opioid receptor signaling in the dorsal raphe through a p38α MAPK-dependent mechanism. J Neurosci 32, 12325-36
22956823   Curated Info

3

Clayton CC, Xu M, Chavkin C (2009) Tyrosine phosphorylation of Kir3 following kappa-opioid receptor activation of p38 MAPK causes heterologous desensitization. J Biol Chem 284, 31872-81
19773548   Curated Info