Ser435

Site Information
EMFSGELsWsADsIR SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 26389900

In vivo Characterization
Methods used to characterize site in vivo:	[32P] bio-synthetic labeling ( 3 ) , mass spectrometry ( 1 ) , mutation of modification site ( 1 , 2 , 3 ) , western blotting ( 1 )
Disease tissue studied:	fibrosarcoma of soft tissue ( 1 )
Relevant cell line - cell type - tissue:	293 (epithelial) ( 1 ) , 2fTGH (fibroblast) ( 3 ) , E.coli (bacterial) ( 2 ) , HT1080 (fibroblast) ( 1 )

Downstream Regulation
Effects of modification on IRF5:	activity, induced ( 2 ) , intracellular localization ( 1 )
Effects of modification on biological processes:	apoptosis, induced ( 1 ) , transcription, induced ( 1 )

References
1	Chang Foreman HC, Van Scoy S, Cheng TF, Reich NC (2012) Activation of interferon regulatory factor 5 by site specific phosphorylation. PLoS One 7, e33098 22412986 Curated Info
2	Chen W, et al. (2008) Insights into interferon regulatory factor activation from the crystal structure of dimeric IRF5. Nat Struct Mol Biol 15, 1213-20 18836453 Curated Info
3	Barnes BJ, Kellum MJ, Field AE, Pitha PM (2002) Multiple regulatory domains of IRF-5 control activation, cellular localization, and induction of chemokines that mediate recruitment of T lymphocytes. Mol Cell Biol 22, 5721-40 12138184 Curated Info