Ser616
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Home > Phosphorylation Site Page: > Ser616  -  Kv4.2 (mouse)

Site Information
EGDDRPEsPEYsGGN   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 457613

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 ) , microscopy-colocalization with upstream kinase ( 4 ) , mutation of modification site ( 2 , 4 , 5 , 6 ) , phospho-antibody ( 1 , 2 , 3 , 6 ) , western blotting ( 1 , 2 , 3 , 6 )
Relevant cell line - cell type - tissue:
'brain, hippocampus' ( 6 ) , 'brain, hippocampus, CA1 region' ( 3 ) , 'brain, nucleus accumbens' ( 1 ) , 'brain, thalamus' ( 2 ) , 'neuron, dorsal horn'-spinal cord ( 5 ) , 'neuron, dorsal horn'-spinal cord [Kv4.2 (mouse)] ( 4 ) , 293 (epithelial) ( 2 ) , COS (fibroblast) ( 6 ) , neuron-'brain, hippocampus' ( 3 )

Upstream Regulation
Putative in vivo kinases:
ERK1 (mouse) ( 4 , 5 ) , ERK2 (mouse) ( 4 , 5 , 6 ) , GSK3B (mouse) ( 1 , 2 , 3 )
Treatments:
beta-amyloid_42 ( 3 ) , chronic unpredictable stress ( 1 ) , CT-99021 ( 3 ) , GSK-3_Inhibitor_XVI ( 1 , 2 ) , siRNA ( 1 ) , triciribine ( 2 )

Downstream Regulation
Effects of modification on Kv4.2:
activity, induced ( 4 , 5 ) , activity, inhibited ( 2 )
Effects of modification on biological processes:
neural plasticity ( 1 )

Disease / Diagnostics Relevance
Relevant diseases:
Alzheimer's disease ( 3 )

References 

1

Aceto G, et al. (2020) Chronic mild stress alters synaptic plasticity in the nucleus accumbens through GSK3β-dependent modulation of Kv4.2 channels. Proc Natl Acad Sci U S A 117
32209671   Curated Info

2

Aceto G, et al. (2018) GSK3β Modulates Timing-Dependent Long-Term Depression Through Direct Phosphorylation of Kv4.2 Channels. Cereb Cortex
29790931   Curated Info

3

Scala F, et al. (2015) Intraneuronal Aβ accumulation induces hippocampal neuron hyperexcitability through A-type K(+) current inhibition mediated by activation of caspases and GSK-3. Neurobiol Aging 36, 886-900
25541422   Curated Info

4

Hu HJ, et al. (2007) Metabotropic glutamate receptor 5 modulates nociceptive plasticity via extracellular signal-regulated kinase-Kv4.2 signaling in spinal cord dorsal horn neurons. J Neurosci 27, 13181-91
18045912   Curated Info

5

Hu HJ, et al. (2006) The kv4.2 potassium channel subunit is required for pain plasticity. Neuron 50, 89-100
16600858   Curated Info

6

Schrader LA, et al. (2006) ERK/MAPK regulates the Kv4.2 potassium channel by direct phosphorylation of the pore-forming subunit. Am J Physiol Cell Physiol 290, C852-61
16251476   Curated Info