Thr607
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Home > Phosphorylation Site Page: > Thr607  -  Kv4.2 (mouse)

Site Information
IPtPPVttPEGDDRP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 457612

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 1 ) , microscopy-colocalization with upstream kinase ( 1 , 2 ) , mutation of modification site ( 1 , 2 , 3 ) , phospho-antibody ( 1 , 3 ) , western blotting ( 1 , 3 )
Relevant cell line - cell type - tissue:
'brain, hippocampus' ( 1 , 3 ) , 'neuron, dorsal horn'-spinal cord [Kv4.2 (mouse)] ( 2 ) , COS (fibroblast) ( 3 ) , HEK293T (epithelial) ( 1 )

Upstream Regulation
Putative in vivo kinases:
ERK2 (human) ( 3 ) , P38A (mouse) ( 1 )
Treatments:
kainic_acid ( 1 ) , SB203580 ( 1 )

Downstream Regulation
Effects of modification on Kv4.2:
activity, induced ( 3 )
Effects of modification on biological processes:
neural plasticity ( 1 )

References 

1

Hu JH, Malloy C, Hoffman DA (2020) P38 Regulates Kainic Acid-Induced Seizure and Neuronal Firing via Kv4.2 Phosphorylation. Int J Mol Sci 21
32824677   Curated Info

2

Hu HJ, et al. (2007) Metabotropic glutamate receptor 5 modulates nociceptive plasticity via extracellular signal-regulated kinase-Kv4.2 signaling in spinal cord dorsal horn neurons. J Neurosci 27, 13181-91
18045912   Curated Info

3

Schrader LA, et al. (2006) ERK/MAPK regulates the Kv4.2 potassium channel by direct phosphorylation of the pore-forming subunit. Am J Physiol Cell Physiol 290, C852-61
16251476   Curated Info