Thr602
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Home > Phosphorylation Site Page: > Thr602  -  Kv4.2 (mouse)

Site Information
TAIISIPtPPVttPE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 457611

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 ) , microscopy-colocalization with upstream kinase ( 2 ) , mutation of modification site ( 2 , 3 ) , phospho-antibody ( 3 ) , western blotting ( 3 )
Relevant cell line - cell type - tissue:
'brain, hippocampus' ( 3 ) , 'neuron, dorsal horn'-spinal cord [Kv4.2 (mouse)] ( 2 ) , brain ( 1 ) , COS (fibroblast) ( 3 )

Upstream Regulation
Putative in vivo kinases:
ERK2 (human) ( 3 )

References 

1

Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89
21183079   Curated Info

2

Hu HJ, et al. (2007) Metabotropic glutamate receptor 5 modulates nociceptive plasticity via extracellular signal-regulated kinase-Kv4.2 signaling in spinal cord dorsal horn neurons. J Neurosci 27, 13181-91
18045912   Curated Info

3

Schrader LA, et al. (2006) ERK/MAPK regulates the Kv4.2 potassium channel by direct phosphorylation of the pore-forming subunit. Am J Physiol Cell Physiol 290, C852-61
16251476   Curated Info