Tyr12
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Home > Phosphorylation Site Page: > Tyr12  -  GIRK1 (rat)

Site Information
RRKFGDDyQVVTTSS   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 457610

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 2 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
neuroblastoma ( 1 ) , pituitary cancer ( 1 )
Relevant cell line - cell type - tissue:
3T3 (fibroblast) [TrkB (mouse)] ( 1 ) , AtT20 (pituitary cell) [GIRK1 (mouse)] ( 1 ) , myocyte ( 1 ) , neuron-dorsal root ganglia ( 1 ) , oocyte ( 2 ) , SH-SY5Y (neural crest) ( 1 ) , spinal cord ( 1 )

Upstream Regulation
Treatments:
anisomycin ( 1 ) , BDNF ( 1 , 2 ) , H2O2 ( 1 ) , inflammation ( 1 ) , K252a ( 1 ) , nerve_damage ( 1 ) , PAO ( 1 ) , swim stress ( 1 )

Downstream Regulation
Effects of modification on GIRK1:
activity, inhibited ( 2 )

References 

1

Ippolito DL, et al. (2005) Tyrosine phosphorylation of K(ir)3.1 in spinal cord is induced by acute inflammation, chronic neuropathic pain, and behavioral stress. J Biol Chem 280, 41683-93
16223722   Curated Info

2

Rogalski SL, et al. (2000) TrkB activation by brain-derived neurotrophic factor inhibits the G protein-gated inward rectifier Kir3 by tyrosine phosphorylation of the channel. J Biol Chem 275, 25082-8
10833508   Curated Info