Ser38
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.5.9.3
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Ser38  -  AID (mouse)

Site Information
YVVKRRDsATsCSLD   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 457604

In vivo Characterization
Methods used to characterize site in vivo:
flow cytometry ( 3 ) , immunoprecipitation ( 1 , 7 ) , mass spectrometry ( 7 , 8 ) , mutation of modification site ( 1 , 3 , 4 , 6 , 7 , 8 ) , phospho-antibody ( 2 , 3 , 5 , 6 , 7 ) , western blotting ( 2 , 3 , 5 , 6 , 7 )
Disease tissue studied:
lymphoma ( 6 ) , B cell lymphoma ( 6 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 8 ) , 3T3 (fibroblast) ( 7 ) , B lymphocyte ( 4 , 5 ) , B lymphocyte-spleen ( 3 , 7 , 8 ) , DT40 (B lymphocyte) [AID (mouse)] ( 6 ) , HEK293T (epithelial) ( 2 , 7 ) , kidney ( 5 ) , lymphocyte-blood ( 1 )

Upstream Regulation
Kinases, in vitro:
PKACA (human) ( 4 , 7 , 8 )
Treatments:
anti-CD40 ( 7 ) , CpG ( 7 ) , IL-4 ( 7 ) , LPS ( 7 )

Downstream Regulation
Effects of modification on AID:
enzymatic activity, induced ( 4 , 7 , 8 ) , intracellular localization ( 1 ) , molecular association, regulation ( 1 , 8 )
Effects of modification on biological processes:
chromatin organization, altered ( 6 ) , DNA repair, inhibited ( 1 )
Induce interaction with:
DNA ( 7 ) , RPA1 (human) ( 8 ) , RPA1 (mouse) ( 1 )

References 

1

Yamane A, et al. (2011) Deep-sequencing identification of the genomic targets of the cytidine deaminase AID and its cofactor RPA in B lymphocytes. Nat Immunol 12, 62-9
21113164   Curated Info

2

Pavri R, et al. (2010) Activation-induced cytidine deaminase targets DNA at sites of RNA polymerase II stalling by interaction with Spt5. Cell 143, 122-33
20887897   Curated Info

3

McBride KM, et al. (2008) Regulation of class switch recombination and somatic mutation by AID phosphorylation. J Exp Med 205, 2585-94
18838546   Curated Info

4

Basu U, Wang Y, Alt FW (2008) Evolution of phosphorylation-dependent regulation of activation-induced cytidine deaminase. Mol Cell 32, 285-91
18951095   Curated Info

5

Shen HM, et al. (2008) Expression of AID transgene is regulated in activated B cells but not in resting B cells and kidney. Mol Immunol 45, 1883-92
18067961   Curated Info

6

Chatterji M, Unniraman S, McBride KM, Schatz DG (2007) Role of activation-induced deaminase protein kinase A phosphorylation sites in Ig gene conversion and somatic hypermutation. J Immunol 179, 5274-80
17911613   Curated Info

7

McBride KM, et al. (2006) Regulation of hypermutation by activation-induced cytidine deaminase phosphorylation. Proc Natl Acad Sci U S A 103, 8798-803
16723391   Curated Info

8

Basu U, et al. (2005) The AID antibody diversification enzyme is regulated by protein kinase A phosphorylation. Nature 438, 508-11
16251902   Curated Info