Thr1078
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Site Information
EHAFYEFtFRRFFDD   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 457595

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 5 ) , phospho-antibody ( 1 , 2 , 3 , 4 , 5 , 6 ) , western blotting ( 1 , 2 , 3 , 4 , 5 , 6 )
Relevant cell line - cell type - tissue:
granulosa ( 5 ) , HEK293-A (epithelial) ( 1 , 2 ) , liver ( 1 ) , MEL (erythroid) ( 3 ) , MMTV-PyMT (breast cell) ( 6 ) , OMM-1 ( 4 ) , OMM2.3 ( 4 ) , ovary ( 5 )

Upstream Regulation
Regulatory protein:
KIBRA (human) ( 2 ) , MST1 (human) ( 1 ) , MST2 (human) ( 1 ) , RAP2A (human) ( 2 ) , SAC (human) ( 3 ) , SAV1 (human) ( 2 ) , WWC2 (human) ( 2 ) , WWC3 (human) ( 2 )
Treatments:
chorionic_gonadotropin ( 5 ) , Elesclomol ( 4 ) , LH ( 5 ) , NAC ( 4 ) , racepinefrine ( 1 ) , rotenone ( 4 )

Downstream Regulation
Effects of modification on biological processes:
apoptosis, induced ( 4 ) , carcinogenesis, inhibited ( 4 ) , cell growth, inhibited ( 4 ) , cell motility, inhibited ( 4 ) , transcription, inhibited ( 4 )

References 

1

Lin TY, et al. (2023) Epinephrine inhibits PI3Kα via the Hippo kinases. Cell Rep 42, 113535
38060450   Curated Info

2

Qi S, et al. (2023) Two Hippo signaling modules orchestrate liver size and tumorigenesis. EMBO J, e112126
36919851   Curated Info

3

Drozdz MM, et al. (2022) A nuclear cAMP microdomain suppresses tumor growth by Hippo pathway inactivation. Cell Rep 40, 111412
36170819   Curated Info

4

Li Y, et al. (2022) Copper ionophore elesclomol selectively targets GNAQ/11-mutant uveal melanoma. Oncogene 41, 3539-3553
35697803   Curated Info

5

Godin P, et al. (2022) The granulosa cell response to luteinizing hormone is partly mediated by YAP1-dependent induction of amphiregulin. Cell Commun Signal 20, 72
35619099   Curated Info

6

Calvo F, et al. (2013) Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts. Nat Cell Biol 15, 637-46
23708000   Curated Info

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